Abstract: Accurate assessment of volume status remains a major challenge in medicine for management of both chronic diseases and acute conditions. Traditional vital signs such as heart rate, blood pressure, and oxygen saturation often provide non-specific or late indications of cardiovascular performance in patients with sub-optimal volume status. This limitation leads to poorer outcomes and increased mortality in conditions such as heart failure and hemorrhage. Our group has developed novel multi-modal sensing devices for non-invasively obtaining a combination of cardiac electrophysiology and cardio-mechanical signals from which we then derive clinically relevant information on volume status in both heart failure (volume overload) and hemorrhage (hypovolemia) conditions. We leverage machine learning and deep learning models to reduce noise, assess signal quality, and map these measurements to physiological parameters that otherwise require implantable devices or cardiac catheterization. This work has led to the founding of a start-up venture, Cardiosense, that is commercializing these technologies for patients with heart failure. This talk will discuss the progression of our technological development from (1) early stage discoveries linking cardio-mechanical signals to volume status, to (2) the development of the wearable device that is now manufactured by Cardiosense and FDA 510(k) cleared, and finally to (3) future opportunities enabled by this technology in hemorrhage management and other clinical applications.
Bio: Omer T. Inan, PhD is Regents Entrepreneur and Smith Chaired Professor in the School of Electrical and Computer Engineering, and Adjunct Professor in the Coulter Department of Biomedical Engineering, at Georgia Tech. He is also Chief Scientific Officer (part-time) and co-founder of Cardiosense, Inc. He received his BS, MS, and PhD in Electrical Engineering from Stanford in 2004, 2005, and 2009, respectively. From 2009-2013, he was the Chief Engineer at Countryman Associates, Inc., a professional audio manufacturer of miniature microphones and high-end audio products for Broadway theaters, theme parks, and broadcast networks. His research focuses on non-invasive physiological sensing and modulation for human health and performance. He has published more than 425 technical articles in peer-reviewed international journals and conferences, and has 21 issued patents. He has received several major awards for his research including the NSF CAREER award, the Office of Naval Research Young Investigator award, and the IEEE Sensors Council Early Career award. He also received an Academy Award for Technical Achievement from The Academy of Motion Picture Arts and Sciences (The Oscars). He is a Fellow of the IEEE, the American Institute for Medical and Biological Engineering (AIMBE), and the American College of Cardiology. He was an IEEE Engineering in Medicine and Biology Society Distinguished Lecturer from 2023-2024. While at Stanford as an undergraduate, he was the school record holder and a three-time National Collegiate Athletic Association All-American in the discus throw.