Continuous biomanufacturing is a growing trend in the biopharmaceutical industry. Ideas from micro/nanofluidics can be employed in all aspects of continuous biomanufacturing to enhance the overall productivity as well as the quality and safety of the products.
In his talk titled “Novel Micro/Nanofluidic System for Separation and Monitoring of Cells and Proteins in Perfusion,” Dr. Taehong Kwon presented novel high-throughput microfluidic cell separation and nanofluidic protein quality monitoring technologies for continuous biomanufacturing. The novel cell retention device based on inertial sorting enabled long-term clog-free perfusion culture with high product recovery. Moreover, as a robust online sensor, the new nanofluidic filter array device achieved continuous online purity monitoring of the proteins in the cell culture supernatant during perfusion culture. This innovative approach is expected to contribute to long-term reliable and efficient biomanufacturing in the future.
Taehong Kwon conducted his Ph.D. under the supervision of Professor Jongyoon Han in the department of Electrical Engineering and Computer Science at MIT. He collaborated with Dr. Jean-François P. Hamel in the department of Chemical Engineering at MIT.
Photos of the seminar can be found here.
Congratulations Taehong!
--Microsystems Technology Laboratories